Comparison of Mineral Trioxide Aggregate and DilutedFormocresol in Pulpotomized Human Primary Molars: A Retrospective Study

Project Name:
Comparison of Mineral Trioxide Aggregate and DilutedFormocresol in Pulpotomized Human Primary Molars: A Retrospective Study
Project Type:
Description:
Formocresol (FC) is the most widely used pulpotomy medicament in the primary dentition. There are concerns associated with this medicament, primarily the carcinogenicity of the chemical and internal resorption of the treated tooth. Alternative pulp therapeutics have been investigated but none have been adopted as the current standard of care. In the recent decade, Mineral Trioxide Aggregate (MTA) has been tested as a pulpal medicament with promising results clinically and radiographically. This study focuses on determining whether gray Mineral Trioxide Aggregate (GMTA) demonstrated therapeutic efficacy in the pulpotomy of human primary molar teeth. Based on power analysis assuming 20% attrition, 250 primary molars from about two hundred patients will be reviewed at each of the two sites. Patients, age 2.5 to 10 year-old, of North Calgary Pediatric Dentistry Clinic at Calgary, Canada, who received pulpotomy treatment with either dilute formocresol (DFC) or gray mineral trioxide aggregate (GMTA) between February 2009 and February 2011 will be evaluated. Patients age 2.5 to 10 years old who received pulptomy treatment with either dilute formocresol (DFC) or gray mineral trioxide aggregate (GMTA) between February 2009 and February 2011 at Mott Children’s Health Center (MCHC), Pediatric Dental Clinic, located in Flint, Michigan will be assessed separately. The review will be conducted at each site by both Drs. Ghoniem and Vaidyanathan based on established selection criteria and evaluation procedure. Clinical evaluation of the pulpotomized molars at each 6 months follow up visit will be recorded in a data spreadsheet and all radiographic records will be scanned and evaluated by three independent evaluators blinded to the treatment group. Clinical and radiographic data will be documented at 6, 12, 18, 24, 30, 36, 42, and 48 months post-treatment. Statistical percentage will be used to summarize categorical data. Statistical analysis will be applied using the SPSS program to assess the treatment?s success rates at the various follow-up periods. Survival analysis will be conducted and the differences of treatment outcomes will be statistically analyzed using chi-square test, Fisher exact test, and t test, using a statistical significance at p<0.05.
Keywords:
Dentist, Dentistry, minearl trioxide aggregate and diluted, Canada, pulpotomy treatment medicament, children, DFC, dilute formocresol, Mott Children Health Center, MCHC, Pediatric Dental Clinic
Project Audience:
Children
Project End Date:
12/31/2015
Project Funder:
Delta Dental Foundation
Project Funding:
3000
Project Principal Investigator:
Jan Ching Chun Hu
Key Personnel:
n/a
Lead Institution:
University of Michigan School of Dentistry
Current Academic Partners:
n/a
Current Community Partners:
n/a
Needed Academic Partners:
n/a
Needed Community Partners:
n/a
Project Contact Name:
n/a
Project Contact Other Email:
n/a

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